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Literature summary for 7.2.2.11 extracted from

  • Fischer, F.; Robbe-Saule, M.; Turlin, E.; Mancuso, F.; Michel, V.; Richaud, P.; Veyrier, F.; De Reuse, H.; Vinella, D.
    Characterization in Helicobacter pylori of a nickel transporter essential for colonization that was acquired during evolution by gastric Helicobacter species (2016), PLoS Pathog., 12, e1006018 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.11

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
-
 Helicobacter pylori
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Bi3+-[bismuth-binding protein][side 1] Helicobacter pylori
-
 ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
ATP + H2O + Bi3+-[bismuth-binding protein][side 1] Helicobacter pylori G27
-
 ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
ATP + H2O + Co2+-[cobalt-binding protein][side 1] Helicobacter pylori
-
 ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
ATP + H2O + Co2+-[cobalt-binding protein][side 1] Helicobacter pylori G27
-
 ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
ATP + H2O + Ni2+-[nickel-binding protein][side 1] Helicobacter pylori
-
 ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?
ATP + H2O + Ni2+-[nickel-binding protein][side 1] Helicobacter pylori G27
-
 ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori G27
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Bi3+-[bismuth-binding protein][side 1]
-
 Helicobacter pylori ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
ATP + H2O + Bi3+-[bismuth-binding protein][side 1]
-
 Helicobacter pylori G27 ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
ATP + H2O + Co2+-[cobalt-binding protein][side 1]
-
 Helicobacter pylori ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
ATP + H2O + Co2+-[cobalt-binding protein][side 1]
-
 Helicobacter pylori G27 ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
ATP + H2O + Ni2+-[nickel-binding protein][side 1]
-
 Helicobacter pylori ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?
ATP + H2O + Ni2+-[nickel-binding protein][side 1]
-
 Helicobacter pylori G27 ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
nickel transporter
-
 Helicobacter pylori
NiuBDE
-
 Helicobacter pylori

General Information

General Information Comment Organism
physiological function the enzyme is indispensable for colonization of the mouse model by Helicobacter pylori. The enzyme participates in nickel-dependent urease activation at pH 5.0 and survival under acidic conditions mimicking those encountered in the stomach. The enzyme is also able to carry out this activity at neutral pH and is essential for colonization of the mouse stomach Helicobacter pylori